Everything about Arteriovenous Malformation totally explained
:
AVM isn't to be confused with AMV.
Arteriovenous malformation or
AVM is a
congenital disorder of the connections between
veins and
arteries in the
vascular system. The genetic transmission patterns of AVM (if any) are unknown, and AVM isn't generally thought to be an inherited disorder--unless in the context of a specific hereditary
syndrome.
Pathophysiology
Arteries and veins are part of the
human cardiovascular system. Normally, the arteries in the vascular system carry oxygen-rich blood at a relatively high pressure. Structurally, arteries divide and sub-divide repeatedly, eventually forming a sponge-like
capillary bed. Blood moves through the capillaries, giving up oxygen and taking up waste products from the surrounding cells. Capillaries successively join together, one upon the other, to form the veins that carry blood away at a relatively low pressure. The heart acts to pump blood from the high pressure arteries to the low pressure veins.
If the capillary bed is thought of as a sponge, then an AVM is the rough equivalent of jamming a tangle of
flexible soda straws from artery to vein through that sponge. On
arteriogram films AVM formation often resemble a tangle of
spaghetti noodles. This tangle of blood vessels forms a relatively direct connection between high pressure arteries and low pressure veins.
The result is a collection of blood vessels with abnormal connections and no
capillaries. This collection, often called a
nidus, can be extremely fragile and prone to bleeding.
Presentation
AVMs can occur in various parts of the body including the
brain (see
cerebral arteriovenous malformation),
spleen,
lung,
kidney,
spinal column, and
liver. AVMs may occur in isolation or as a part of another disease (for example
Von Hippel-Lindau disease or
hereditary hemorrhagic telangiectasia).
This bleeding can be devastating, particularly in the brain. It can cause severe and often fatal
strokes. If detected before a stroke occurs, usually the arteries feeding blood into the nidus can be closed off, ensuring the safety of the patient.
Noteworthy cases
Stuart Sutcliffe, the Beatles' original bassist, died of a brain hemorrhage in 1962. It was originally thought to have been caused by blows to the head during various scuffles in seedy sections of Liverpool, but it's now believed to have been caused by AVM.
A.J. Price, a point guard on the University of Connecticut Men's Basketball team was diagnosed with AVM in 2004 and was treated with a series of radiosurgeries
Cases in fiction
The plot of William Finn's 1998 Off-Broadway musical, A New Brain, revolves around the main character's battle with AVM.
The character Nate Fisher on the HBO television show Six Feet Under suffers from AVM.
An episode of the television sit-com Becker used a cerebral AVM as a plot device.
The character John Henry Giles, a fictional jazz legend from the series "House", was eventually diagnosed with AVM in the episode DNR.
An episode of Grey's Anatomy season 1 episode 9, the 'psychic' who is thought to have visions, actually has cerebral AVM.
In Robert J. Sawyer's novel Mindscan, the protagonist has an inherited condition called Katerinsky's syndrome which increases one's risk of having an AVM, which causes him to upload his consciousness to a robot earlier than normal.
In the Media
The Who Had Minutes To Live was a documentary made of AVM sufferer Pete Nash. It follows him as he raises money for his operation that will save his life. He was forced to raise money after the NHS refused to undertake the operation. Further Information
Get more info on 'Arteriovenous Malformation'.
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